Prof. Mrinal Kanti Bhattacharyya, Ph.D.
Professor
Department of Biochemistry
School of Life Sciences
University of Hyderabad
Hyderabad 500 046, India
Phone: +91-40-23134528
Fax: +91-40-23010120
Email: mkbsl@uohyd.ac.in
Mission: Eradicate malaria, save million lives. Vision: Know malaria, no malaria
Research Interests
Our long-term research interest is to unravel how nuclear and chromosomal context influence the seeming inaccuracy in DNA repair that provides a pathogen with the necessary means to manipulate the “host-pathogen interaction”. Thus, research activities in our laboratory mainly revolve around two interlinked questions:
1) What are the mechanisms of DNA repair in Plasmodium, and
2) How do they contribute to genetic diversities that result in antigenic variation, the most potent means of immune evasion?
Selected
Publications
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W. Tabassum, M. Bhattacharya, S. Bakshi and M. K. Bhattacharyya* (2022). Heat Shock Protein 90 regulates the activity of histone deacetylase Sir2 in Plasmodium falciparum. mSphere. 7(5): e0032922
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P. Jha, A. Gahlawat, S. Bhattacharyya, S. Dey, K. A. Kumar and M. K. Bhattacharyya* (2021). Bloom helicase along with recombinase Rad51 repair the mitochondrial genomes of malaria parasites. mSphere. 6(6):e0071821. doi: 10.1128/mSphere.00718-21.
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W. Tabassum, P. Singh, N. Suthram, S. Bhattacharyya* and M. K. Bhattacharyya* (2021). Synergistic action between PfHsp90 inhibitor and PfRad51 inhibitor induces elevated DNA damage sensitivity in the malaria parasite. Antimicrobial Agents and Chemotherapy. 65(9):e0045721. doi: 10.1128/AAC.00457-21.
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W. Tabassum, S. Bhattacharyya, S. M. Varunan and M. K. Bhattacharyya* (2021). Febrile temperature causes transcriptional down-regulation of Plasmodium falciparum Sirtuins through Hsp90 dependent epigenetic modification. Molecular Microbiology. 115(5): 1025-1038.doi: 10.1111/mmi.14692.
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N. Suthram, S. Padhi, P. Jha, S. Bhattacharyya, G. Bulusu, A. Roy and M. K. Bhattacharyya* (2020). Elucidation of DNA Repair Function of PfBlm and Potentiation of Artemisinin Action by a Small-Molecule Inhibitor of RecQ Helicase. mSphere. e00956-20. doi: 10.1128/mSphere.00956-20.
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P. Vydyam, D. Dutta, N. Sutram, S. Bhattacharyya and M. K. Bhattacharyya* (2019). A Small molecule inhibitor of DNA recombinase Rad51 from Plasmodium falciparum synergizes with the anti-malarial drugs artemisinin and chloroquine. Journal of Biological Chemistry, 294(20):8171-8183.
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N. Roy, S. Bhattacharyya, S. Chakrabarty, S. Laskar, S. M. Babu and M. K. Bhattacharyya* (2014). Dominant negative mutant of Plasmodium Rad51 causes reduced parasite burden in host by abrogating DNA double strand break repair. Molecular Microbiology, 94: 2, (353–366).